Does Naproxen And Esomeprazole Magnesium Interact with Clopidogrel?
Naproxen And Esomeprazole Magnesium and Clopidogrel have a contraindicated drug interaction according to U.S. FDA drug labeling data. Esomeprazole 40 mg reduces plasma concentrations of clopidogrel's active metabolite and platelet inhibition. Concomitant use is contraindicated. The mechanism involves reduced plasma concentrations of active metabolite and reduction in platelet inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Naproxen And Esomeprazole Magnesium Class
- Nonsteroidal Anti-inflammatory Drug
- Clopidogrel Class
- P2Y12 Platelet Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Naproxen And Esomeprazole Magnesium and Clopidogrel occurs because reduced plasma concentrations of active metabolite and reduction in platelet inhibition. Clinically, this means esomeprazole 40 mg reduces plasma concentrations of clopidogrel's active metabolite and platelet inhibition. concomitant use is contraindicated. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.
What To Tell Your Doctor or Pharmacist
If you are taking Naproxen And Esomeprazole Magnesium and your doctor is considering prescribing Clopidogrel (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider