Does Naproxen And Esomeprazole Magnesium Interact with Acetylsalicylic Acid?
Naproxen And Esomeprazole Magnesium and Acetylsalicylic Acid have a major drug interaction according to U.S. FDA drug labeling data. Naproxen interferes with antiplatelet effect of low-dose aspirin. Concomitant use with analgesic doses of aspirin increases GI adverse reactions and cardiovascular event risk. The mechanism involves naproxen interference with aspirin's antiplatelet effect. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Naproxen And Esomeprazole Magnesium Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Naproxen And Esomeprazole Magnesium and Acetylsalicylic Acid occurs because naproxen interference with aspirin's antiplatelet effect. Clinically, this means naproxen interferes with antiplatelet effect of low-dose aspirin. concomitant use with analgesic doses of aspirin increases gi adverse reactions and cardiovascular event risk. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Naproxen And Esomeprazole Magnesium and your doctor is considering prescribing Acetylsalicylic Acid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider