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Does Glyburide And Metformin Hydrochloride Interact with Chloramphenicol?

Glyburide And Metformin Hydrochloride and Chloramphenicol have a major drug interaction according to U.S. FDA drug labeling data. Chloramphenicol may potentiate the hypoglycemic action of glyburide. Close observation for hypoglycemia required. The mechanism involves protein binding displacement; potentiation of hypoglycemic action. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Glyburide And Metformin Hydrochloride Class
Sulfonylurea
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Glyburide And Metformin Hydrochloride and Chloramphenicol occurs because protein binding displacement; potentiation of hypoglycemic action. Clinically, this means chloramphenicol may potentiate the hypoglycemic action of glyburide. close observation for hypoglycemia required. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Glyburide And Metformin Hydrochloride and your doctor is considering prescribing Chloramphenicol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Glyburide And Metformin Hydrochloride(Glyburide And Metformin Hydrochloride)+💊 Chloramphenicol

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Sulfonylurea
Drug B class
—
Source
NLP:glyburide and metformin hydrochloride

What this means in plain English

Chloramphenicol may potentiate the hypoglycemic action of glyburide. Close observation for hypoglycemia required.

What the FDA label says

"Protein binding displacement; potentiation of hypoglycemic action"

📖 Source: NLP:glyburide and metformin hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.