Chloramphenicol Interactions

May increase tacrolimus whole blood trough concentrations and increase risk of serious adverse reactions including neurotoxicity and QT prolongation. Reduce tacrolimus dose and adjust based on monitoring.

Source: NLP:tacrolimus

Chloramphenicol may interfere with bactericidal effects of amoxicillin, though clinical significance is not well documented.

Source: NLP:amoxicillin

May interfere with the bactericidal effect of ampicillin.

Source: NLP:ampicillin

Chloramphenicol may decrease the efficacy of Cyanocobalamin Nasal Spray when used for treatment of anemia. Monitor for reduced efficacy and consider alternative therapy if needed.

Source: NLP:cyanocobalamin

Chloramphenicol may interfere with biliary excretion, glucuronidation, and intestinal beta-glucuronidase of entacapone; caution should be exercised.

Source: NLP:entacapone

May increase phenytoin serum levels; monitoring of phenytoin levels recommended.

Source: NLP:fosphenytoin sodium

May potentiate hypoglycemic action of glyburide; patient should be closely observed for hypoglycemia.

Source: NLP:glyburide

Highly protein-bound drug that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Source: NLP:glimepiride

Chloramphenicol may potentiate hypoglycemic action of glipizide. Patient should be observed closely for hypoglycemia when initiated or withdrawn.

Source: NLP:glipizide

May potentiate hypoglycemic action of glyburide; monitor closely for hypoglycemia.

Source: NLP:glyburide and metformin hydrochloride

May potentiate hypoglycemic action of glyburide; monitor for hypoglycemia.

Source: NLP:glyburide-metformin hydrochloride

Oral antibiotics like chloramphenicol may decrease intestinal absorption of methotrexate or interfere with enterohepatic circulation.

Source: NLP:methotrexate

In patients with pernicious anemia, chloramphenicol may inhibit hematologic response to vitamin B12 therapy.

Source: NLP:multiple vitamins injection

Bacteriostatic antibacterial may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.

Source: NLP:penicillin g

Bacteriostatic antibiotic may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.

Source: NLP:penicillin g potassium

May antagonize the bactericidal effect of penicillin. Concurrent use should be avoided, though clinical significance is not well-documented.

Source: NLP:penicillin g sodium

May increase phenytoin serum levels; monitoring of phenytoin levels recommended.

Source: NLP:extended phenytoin sodium