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Does Atorvastatin Calcium Interact with Cyclosporine?

Atorvastatin Calcium and Cyclosporine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Significantly increases atorvastatin plasma levels and increases risk of myopathy and rhabdomyolysis. Concomitant use is not recommended. The mechanism involves inhibition of cyp3a4 and oatp1b1. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Atorvastatin Calcium Class
HMG-CoA Reductase Inhibitor
Cyclosporine Class
Calcineurin Inhibitor Immunosuppressant
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Atorvastatin Calcium and Cyclosporine occurs because inhibition of cyp3a4 and oatp1b1. Clinically, this means significantly increases atorvastatin plasma levels and increases risk of myopathy and rhabdomyolysis. concomitant use is not recommended. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Atorvastatin Calcium and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Atorvastatin Calcium(Atorvastatin Calcium)+💊 Cyclosporine(Neoral)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
HMG-CoA Reductase Inhibitor
Drug B class
Calcineurin Inhibitor Immunosuppressant
Source
NLP:atorvastatin calcium

What this means in plain English

Significantly increases atorvastatin plasma levels and increases risk of myopathy and rhabdomyolysis. Concomitant use is not recommended.

What the FDA label says

"Inhibition of CYP3A4 and OATP1B1"

📖 Source: NLP:atorvastatin calcium

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.