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Thiazide Diuretics

Thiazide diuretics lower blood pressure by increasing urine output. They interact with NSAIDs, lithium, diabetes medications, and other antihypertensives.

23 drugs in this class6 notable interactions shown

Thiazide Diuretics Drugs (23)

Amiloride - Apis Mellifera - Berberis Vulgaris Fruit - Hieracium Pilosella Flowering Top - Hydrochlorothiazide - Solidago Virgaurea Flowering Top - Spironolactone - Sus Scrofa Pituitary Gland -Guna-DiurAmiloride Hydrochloride And HydrochlorothiazideAmiloride Hydrochloride And HydrochlorothiazideBenazepril Hydrochloride And HydrochlorothiazideLotensin HctBisoprolol Fumarate And HydrochlorothiazideBisoprolol Fumarate And HydrochlorothiazideCandesartan Cilexetil And HydrochlorothiazideAtacand HctCaptopril And HydrochlorothiazideCaptopril And HydrochlorothiazideChlorothiazideEnalapril Maleate And HydrochlorothiazideEnalapril Maleate And HydrochlorothiazideFosinopril Sodium And HydrochlorothiazideFosinopril Sodium And HydrochlorothiazideHydrochlorothiazideIrbesartan And HydrochlorothiazideAvalideLisinopril And Hydrochlorothiazide TabletsLisinopril And HydrochlorothiazideLosartan Potassium And HydrochlorothiazideLosartan Potassium And HydrochlorothiazideMetoprolol Tartrate And HydrochlorothiazideMetoprolol Tartrate And HydrochlorothiazideOlmesartan Medoxomil / Amlodipine Besylate / HydrochlorothiazideOlmesartan Medoxomil / Amlodipine Besylate / HydrochlorothiazideOlmesartan Medoxomil And Amlodipine Besylate And HydrochlorothiazideOlmesartan Medoxomil And Amlodipine Besylate And HydrochlorothiazideOlmesartan Medoxomil And HydrochlorothiazideOlmesartan Medoxomil And HydrochlorothiazideOlmesartan Medoxomil-HydrochlorothiazideBenicar HctQuinapril Hydrochloride/HydrochlorothiazideQuinapril Hydrochloride/HydrochlorothiazideSpironolactone And HydrochlorothiazideSpironolactone And HydrochlorothiazideTelmisartan And HydrochlorothiazideTelmisartan And HydrochlorothiazideTriamterene And HydrochlorothiazideTriamterene And HydrochlorothiazideValsartan And HydrochlorothiazideValsartan And Hydrochlorothiazide

Notable Thiazide Diuretics Interactions

Amiloride Hydrochloride And Hydrochlorothiazide + Angiotensin Ii⚠️Major

Risk of hyperkalemia may be increased when amiloride HCl is administered concomitantly. Use with caution and frequent monitoring of serum potassium.

Amiloride Hydrochloride And Hydrochlorothiazide + Cyclosporine⚠️Major

Risk of hyperkalemia may be increased when amiloride HCl is administered concomitantly. Use with caution and frequent monitoring of serum potassium.

Amiloride Hydrochloride And Hydrochlorothiazide + Lithium⚠️Major

Generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

Benazepril Hydrochloride And Hydrochlorothiazide + Aliskiren⛔Contraindicated

Do not coadminister with benazepril/hydrochlorothiazide in patients with diabetes. Avoid in renal impairment (GFR < 60 mL/min) due to increased risks of hyperkalemia and acute renal failure.

Benazepril Hydrochloride And Hydrochlorothiazide + Angiotensin Ii⚠️Major

Dual RAS blockade associated with increased risks of hyperkalemia, hypertension, and acute renal failure. Avoid combined use.

Benazepril Hydrochloride And Hydrochlorothiazide + Everolimus⚠️Major

mTOR inhibitor coadministration with ACE inhibitor may increase risk for angioedema.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.