Amiloride Hydrochloride And Hydrochlorothiazide Interactions

Brand names: Amiloride Hydrochloride And Hydrochlorothiazide

Thiazide Diuretic

FDA Black Box Warning

Like other potassium-conserving diuretic combinations, amiloride and hydrochlorothiazide may cause hyperkalemia (serum potassium levels greater than 5.5 mEq per liter). In patients without renal impairment or diabetes mellitus, the risk of hyperkalemia with this combination product is about 1 to 2 percent. This risk is higher in patients with renal impairment or diabetes mellitus (even without recognized diabetic nephropathy). Since hyperkalemia, if uncorrected, is potentially fatal, it is essential to monitor serum potassium levels carefully in any patient receiving amiloride hydrochloride and hydrochlorothiazide, particularly when it is first introduced, at the time of dosage adjustments, and during any illness that could affect renal function.

1 interaction on record

Amiloride Hydrochloride And Hydrochlorothiazide + HydrochlorothiazideUnknown

Therefore, when amiloride and hydrochlorothiazide plus non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Hydrochlorothiazide When given concurrently the following drugs may interact with thiazide diuretics. Cholestyramine and Colestipol Resins Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.

Source: FDA drug label - amiloride hydrochloride and hydrochlorothiazide