Home›Tranylcypromine Sulfate›Tranylcypromine Sulfate + Fluoxetine

Does Tranylcypromine Sulfate Interact with Fluoxetine?

Tranylcypromine Sulfate and Fluoxetine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Contraindicated due to risk of clinically significant adverse reactions. Minimum 5-week washout period required before starting tranylcypromine due to fluoxetine's long half-life. The mechanism involves serotonin syndrome risk; persistent mao inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Tranylcypromine Sulfate and Fluoxetine occurs because serotonin syndrome risk; persistent mao inhibition. Clinically, this means contraindicated due to risk of clinically significant adverse reactions. minimum 5-week washout period required before starting tranylcypromine due to fluoxetine's long half-life. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Tranylcypromine Sulfate and your doctor is considering prescribing Fluoxetine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tranylcypromine Sulfate(Tranylcypromine Sulfate)+💊 Fluoxetine(Fluoxetine)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:tranylcypromine sulfate

What this means in plain English

Contraindicated due to risk of clinically significant adverse reactions. Minimum 5-week washout period required before starting tranylcypromine due to fluoxetine's long half-life.

What the FDA label says

"Serotonin syndrome risk; persistent MAO inhibition"

📖 Source: NLP:tranylcypromine sulfate

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Tranylcypromine Sulfate and Fluoxetine against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.