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Does Propranolol Hydrochloride Interact with Epinephrine?

Propranolol Hydrochloride and Epinephrine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Patients on long-term propranolol therapy may experience uncontrolled hypertension if administered epinephrine due to unopposed alpha-receptor stimulation. Not indicated for propranolol overdose. The mechanism involves unopposed alpha-receptor stimulation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Epinephrine Class
alpha-Adrenergic Agonist
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Propranolol Hydrochloride and Epinephrine occurs because unopposed alpha-receptor stimulation. Clinically, this means patients on long-term propranolol therapy may experience uncontrolled hypertension if administered epinephrine due to unopposed alpha-receptor stimulation. not indicated for propranolol overdose. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Propranolol Hydrochloride and your doctor is considering prescribing Epinephrine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Propranolol Hydrochloride(Propranolol Hydrochloride)+💊 Epinephrine(Adrenalin)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
alpha-Adrenergic Agonist
Source
NLP:propranolol hydrochloride

What this means in plain English

Patients on long-term propranolol therapy may experience uncontrolled hypertension if administered epinephrine due to unopposed alpha-receptor stimulation. Not indicated for propranolol overdose.

What the FDA label says

"Unopposed alpha-receptor stimulation"

📖 Source: NLP:propranolol hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.