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Does Paliperidone Palmitate Interact with St Johns Wort?

Paliperidone Palmitate and St Johns Wort have a major drug interaction according to U.S. FDA drug labeling data. Strong CYP3A4/P-gp inducer that may decrease paliperidone exposure. Avoid during 3-month dosing interval if possible; consider paliperidone extended-release tablets if necessary. The mechanism involves cyp3a4/p-gp induction decreases paliperidone exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Paliperidone Palmitate and St Johns Wort occurs because cyp3a4/p-gp induction decreases paliperidone exposure. Clinically, this means strong cyp3a4/p-gp inducer that may decrease paliperidone exposure. avoid during 3-month dosing interval if possible; consider paliperidone extended-release tablets if necessary. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Paliperidone Palmitate and your doctor is considering prescribing St Johns Wort (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Paliperidone Palmitate(Invega Hafyera)+💊 St Johns Wort

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:paliperidone palmitate

What this means in plain English

Strong CYP3A4/P-gp inducer that may decrease paliperidone exposure. Avoid during 3-month dosing interval if possible; consider paliperidone extended-release tablets if necessary.

What the FDA label says

"CYP3A4/P-gp induction decreases paliperidone exposure"

📖 Source: NLP:paliperidone palmitate

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.