Does Olmesartan Medoxomil Hydrochlorothiazide Interact with Nsaids?
Olmesartan Medoxomil Hydrochlorothiazide and Nsaids have a major drug interaction according to U.S. FDA drug labeling data. Co-administration may result in deterioration of renal function, including possible acute renal failure, and may attenuate antihypertensive effects. Monitor renal function and blood pressure. The mechanism involves nsaids impair renal function when combined with angiotensin ii receptor antagonists and reduce diuretic and antihypertensive effects of thiazides. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Olmesartan Medoxomil Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Olmesartan Medoxomil Hydrochlorothiazide and Nsaids occurs because nsaids impair renal function when combined with angiotensin ii receptor antagonists and reduce diuretic and antihypertensive effects of thiazides. Clinically, this means co-administration may result in deterioration of renal function, including possible acute renal failure, and may attenuate antihypertensive effects. monitor renal function and blood pressure. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Olmesartan Medoxomil Hydrochlorothiazide and your doctor is considering prescribing Nsaids (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider