Does Ofloxacin Ophthalmic Solution Usp 03 Interact with Theophylline?
Ofloxacin Ophthalmic Solution Usp 03 and Theophylline have a moderate drug interaction according to U.S. FDA drug labeling data. Systemic quinolone administration has been shown to elevate plasma concentrations of theophylline. The mechanism involves quinolone-mediated elevation of theophylline plasma concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Ofloxacin Ophthalmic Solution Usp 03 Class
- Quinolone Antimicrobial
- Theophylline Class
- Methylxanthine
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ofloxacin Ophthalmic Solution Usp 03 and Theophylline occurs because quinolone-mediated elevation of theophylline plasma concentrations. Clinically, this means systemic quinolone administration has been shown to elevate plasma concentrations of theophylline. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Ofloxacin Ophthalmic Solution Usp 03 and your doctor is considering prescribing Theophylline (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider