Does Minocycline Hydrochloride Extended Release Interact with Antacids Containing Calcium Magnesium Or Aluminum?
Minocycline Hydrochloride Extended Release and Antacids Containing Calcium Magnesium Or Aluminum have a moderate drug interaction according to U.S. FDA drug labeling data. Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium. The mechanism involves impaired absorption of tetracyclines. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Minocycline Hydrochloride Extended Release and Antacids Containing Calcium Magnesium Or Aluminum occurs because impaired absorption of tetracyclines. Clinically, this means absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Minocycline Hydrochloride Extended Release and your doctor is considering prescribing Antacids Containing Calcium Magnesium Or Aluminum (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider