HomeMidodrine HydrochlorideMidodrine Hydrochloride + Monoamine Oxidase Inhibitors Maois

Does Midodrine Hydrochloride Interact with Monoamine Oxidase Inhibitors Maois?

Midodrine Hydrochloride and Monoamine Oxidase Inhibitors Maois have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use with midodrine should be avoided. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Midodrine Hydrochloride and your doctor is considering prescribing Monoamine Oxidase Inhibitors Maois (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Midodrine Hydrochloride(Midodrine Hydrochloride)+💊 Monoamine Oxidase Inhibitors Maois

Severity & Interaction Details

contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Drug B class
Source
NLP:midodrine hydrochloride
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Check Midodrine Hydrochloride and Monoamine Oxidase Inhibitors Maois against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.