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Does Lorlatinib Interact with Cyp3a Inducers?

Lorlatinib and Cyp3a Inducers have a contraindicated drug interaction according to U.S. FDA drug labeling data. Strong CYP3A inducers are contraindicated with lorlatinib. Concomitant use decreases lorlatinib plasma concentrations, which may decrease efficacy. The mechanism involves cyp3a induction decreases lorlatinib metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Lorlatinib Class
Kinase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Lorlatinib and Cyp3a Inducers occurs because cyp3a induction decreases lorlatinib metabolism. Clinically, this means strong cyp3a inducers are contraindicated with lorlatinib. concomitant use decreases lorlatinib plasma concentrations, which may decrease efficacy. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Lorlatinib and your doctor is considering prescribing Cyp3a Inducers (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Lorlatinib(Lorbrena)+💊 Cyp3a Inducers

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Kinase Inhibitor
Drug B class
—
Source
NLP:lorlatinib

What this means in plain English

Strong CYP3A inducers are contraindicated with lorlatinib. Concomitant use decreases lorlatinib plasma concentrations, which may decrease efficacy.

What the FDA label says

"CYP3A induction decreases lorlatinib metabolism"

📖 Source: NLP:lorlatinib

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.