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Does Labetalol Hydrochloride Interact with Nonselective Beta Adrenergic Antagonists?

Labetalol Hydrochloride and Nonselective Beta Adrenergic Antagonists have a contraindicated drug interaction according to U.S. FDA drug labeling data. Labetalol antagonizes the bronchodilatory effect of beta-receptor agonist drugs and is contraindicated in patients with bronchial asthma. The mechanism involves beta blockers antagonize the bronchodilator effect of beta-receptor agonists. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Labetalol Hydrochloride Class
beta-Adrenergic Blocker
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Labetalol Hydrochloride and Nonselective Beta Adrenergic Antagonists occurs because beta blockers antagonize the bronchodilator effect of beta-receptor agonists. Clinically, this means labetalol antagonizes the bronchodilatory effect of beta-receptor agonist drugs and is contraindicated in patients with bronchial asthma. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Labetalol Hydrochloride and your doctor is considering prescribing Nonselective Beta Adrenergic Antagonists (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Labetalol Hydrochloride(Labetalol Hydrochloride)+💊 Nonselective Beta Adrenergic Antagonists

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
beta-Adrenergic Blocker
Drug B class
—
Source
NLP:labetalol hydrochloride

What this means in plain English

Labetalol antagonizes the bronchodilatory effect of beta-receptor agonist drugs and is contraindicated in patients with bronchial asthma.

What the FDA label says

"Beta blockers antagonize the bronchodilator effect of beta-receptor agonists"

📖 Source: NLP:labetalol hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.