Does Heparin Interact with Andexanet Alfa?
Heparin and Andexanet Alfa have a contraindicated drug interaction according to U.S. FDA drug labeling data. Unresponsiveness to unfractionated heparin following ANDEXANET ALFA administration, characterized by non-prolongation of activated clotting times and requirement for increased heparin dosing. Do not use unfractionated heparin following ANDEXANET ALFA administration. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Heparin and your doctor is considering prescribing Andexanet Alfa (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider