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Does Ezetimibe And Simvastatin Interact with Cobicistat?

Ezetimibe And Simvastatin and Cobicistat have a contraindicated drug interaction according to U.S. FDA drug labeling data. Strong CYP3A4 inhibitor that increases simvastatin plasma levels, elevating risk of myopathy and rhabdomyolysis. The mechanism involves reduces elimination of simvastatin component via cyp3a4 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Ezetimibe And Simvastatin Class
HMG-CoA Reductase Inhibitor
Cobicistat Class
Cytochrome P450 3A Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Ezetimibe And Simvastatin and Cobicistat occurs because reduces elimination of simvastatin component via cyp3a4 inhibition. Clinically, this means strong cyp3a4 inhibitor that increases simvastatin plasma levels, elevating risk of myopathy and rhabdomyolysis. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Ezetimibe And Simvastatin and your doctor is considering prescribing Cobicistat (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Ezetimibe And Simvastatin(Vytorin)+💊 Cobicistat(Tybost)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
HMG-CoA Reductase Inhibitor
Drug B class
Cytochrome P450 3A Inhibitor
Source
NLP:ezetimibe and simvastatin

What this means in plain English

Strong CYP3A4 inhibitor that increases simvastatin plasma levels, elevating risk of myopathy and rhabdomyolysis.

What the FDA label says

"Reduces elimination of simvastatin component via CYP3A4 inhibition"

📖 Source: NLP:ezetimibe and simvastatin

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.