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Does Disulfiram Interact with Bismuth Subcitrate Potassium Metronidazole And Tetracycline ?

Disulfiram and Bismuth Subcitrate Potassium Metronidazole And Tetracycline have a contraindicated drug interaction according to U.S. FDA drug labeling data. Psychotic reactions can occur; do not take concurrently or within the last 2 weeks of disulfiram. The mechanism involves interaction between metronidazole component and disulfiram. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Disulfiram Class
Aldehyde Dehydrogenase Inhibitor
Bismuth Subcitrate Potassium Metronidazole And Tetracycline Class
Nitroimidazole Antimicrobial
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Disulfiram and Bismuth Subcitrate Potassium Metronidazole And Tetracycline occurs because interaction between metronidazole component and disulfiram. Clinically, this means psychotic reactions can occur; do not take concurrently or within the last 2 weeks of disulfiram. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Disulfiram and your doctor is considering prescribing Bismuth Subcitrate Potassium Metronidazole And Tetracycline (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Disulfiram(Disulfiram)+💊 Bismuth Subcitrate Potassium Metronidazole And Tetracycline (Bismuth Subcitrate Potassium, Metronidazole And Tetracycline Hydrochloride)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Aldehyde Dehydrogenase Inhibitor
Drug B class
Nitroimidazole Antimicrobial
Source
NLP:bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride

What this means in plain English

Psychotic reactions can occur; do not take concurrently or within the last 2 weeks of disulfiram.

What the FDA label says

"Interaction between metronidazole component and disulfiram"

📖 Source: NLP:bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.