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Does Digoxin Interact with Calcium Gluconate?

Digoxin and Calcium Gluconate have a contraindicated drug interaction according to U.S. FDA drug labeling data. Hypercalcemia increases risk of digoxin toxicity; synergistic arrhythmias may occur. Avoid concurrent administration; if necessary, administer slowly with ECG monitoring. The mechanism involves hypercalcemia increases digoxin toxicity risk; synergistic arrhythmia potential. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Digoxin Class
Cardiac Glycoside
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Digoxin and Calcium Gluconate occurs because hypercalcemia increases digoxin toxicity risk; synergistic arrhythmia potential. Clinically, this means hypercalcemia increases risk of digoxin toxicity; synergistic arrhythmias may occur. avoid concurrent administration; if necessary, administer slowly with ecg monitoring. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Digoxin and your doctor is considering prescribing Calcium Gluconate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Digoxin(Digoxin)+💊 Calcium Gluconate(Calcium Gluconate)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Cardiac Glycoside
Drug B class
—
Source
NLP:calcium gluconate

What this means in plain English

Hypercalcemia increases risk of digoxin toxicity; synergistic arrhythmias may occur. Avoid concurrent administration; if necessary, administer slowly with ECG monitoring.

What the FDA label says

"Hypercalcemia increases digoxin toxicity risk; synergistic arrhythmia potential"

📖 Source: NLP:calcium gluconate

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.