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Does Desloratadine And Pseudoephedrine Sulfate Interact with Monoamine Oxidase Inhibitors Maois?

Desloratadine And Pseudoephedrine Sulfate and Monoamine Oxidase Inhibitors Maois have a contraindicated drug interaction according to U.S. FDA drug labeling data. MAO inhibitors potentiate the effect of pseudoephedrine on the vascular system. Do not use within 14 days of stopping MAO inhibitor therapy. The mechanism involves potentiation of pseudoephedrine's vascular effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Desloratadine And Pseudoephedrine Sulfate Class
Histamine-1 Receptor Antagonist
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Desloratadine And Pseudoephedrine Sulfate and Monoamine Oxidase Inhibitors Maois occurs because potentiation of pseudoephedrine's vascular effects. Clinically, this means mao inhibitors potentiate the effect of pseudoephedrine on the vascular system. do not use within 14 days of stopping mao inhibitor therapy. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Desloratadine And Pseudoephedrine Sulfate and your doctor is considering prescribing Monoamine Oxidase Inhibitors Maois (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Desloratadine And Pseudoephedrine Sulfate(Clarinex-D 12 Hour)+💊 Monoamine Oxidase Inhibitors Maois

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Histamine-1 Receptor Antagonist
Drug B class
—
Source
NLP:desloratadine and pseudoephedrine sulfate

What this means in plain English

MAO inhibitors potentiate the effect of pseudoephedrine on the vascular system. Do not use within 14 days of stopping MAO inhibitor therapy.

What the FDA label says

"Potentiation of pseudoephedrine's vascular effects"

📖 Source: NLP:desloratadine and pseudoephedrine sulfate

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.