Does Ceftriaxone Interact with Dextrose Soybean Oil Electrolytes Lysine Phenylalanine Leuci?
Ceftriaxone and Dextrose Soybean Oil Electrolytes Lysine Phenylalanine Leuci have a contraindicated drug interaction according to U.S. FDA drug labeling data. Precipitation of ceftriaxone-calcium can occur when mixed in the same IV line. Do not administer ceftriaxone simultaneously via Y-site. Deaths reported in neonates from calcium-ceftriaxone precipitates. The mechanism involves calcium-ceftriaxone precipitation in lungs and kidneys. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Dextrose Soybean Oil Electrolytes Lysine Phenylalanine Leuci Class
- Amino Acid
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ceftriaxone and Dextrose Soybean Oil Electrolytes Lysine Phenylalanine Leuci occurs because calcium-ceftriaxone precipitation in lungs and kidneys. Clinically, this means precipitation of ceftriaxone-calcium can occur when mixed in the same iv line. do not administer ceftriaxone simultaneously via y-site. deaths reported in neonates from calcium-ceftriaxone precipitates. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.
What To Tell Your Doctor or Pharmacist
If you are taking Ceftriaxone and your doctor is considering prescribing Dextrose Soybean Oil Electrolytes Lysine Phenylalanine Leuci (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider