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Does Cabotegravir Sodium Interact with Drugs That Are Strong Inducers Of Ugt1a1?

Cabotegravir Sodium and Drugs That Are Strong Inducers Of Ugt1a1 have a contraindicated drug interaction according to U.S. FDA drug labeling data. Strong UGT1A1 inducers decrease cabotegravir plasma concentrations and may result in loss of efficacy. The mechanism involves ugt1a1 induction decreases cabotegravir metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cabotegravir Sodium and Drugs That Are Strong Inducers Of Ugt1a1 occurs because ugt1a1 induction decreases cabotegravir metabolism. Clinically, this means strong ugt1a1 inducers decrease cabotegravir plasma concentrations and may result in loss of efficacy. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Cabotegravir Sodium and your doctor is considering prescribing Drugs That Are Strong Inducers Of Ugt1a1 (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cabotegravir Sodium(Vocabria)+💊 Drugs That Are Strong Inducers Of Ugt1a1

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:cabotegravir sodium

What this means in plain English

Strong UGT1A1 inducers decrease cabotegravir plasma concentrations and may result in loss of efficacy.

What the FDA label says

"UGT1A1 induction decreases cabotegravir metabolism"

📖 Source: NLP:cabotegravir sodium

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.