Does Brompheniramine Maleate Pseudoephedrine Hydrochloride And De Interact with Monoamine Oxidase Inhibitors Maois?
Brompheniramine Maleate Pseudoephedrine Hydrochloride And De and Monoamine Oxidase Inhibitors Maois have a contraindicated drug interaction according to U.S. FDA drug labeling data. Hyperpyrexia, hypotension, and death reported with coadministration. MAO inhibitors prolong/intensify anticholinergic effects and enhance pseudoephedrine effect. The mechanism involves mao inhibitor interaction with dextromethorphan; potentiation of anticholinergic and sympathomimetic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Brompheniramine Maleate Pseudoephedrine Hydrochloride And De and Monoamine Oxidase Inhibitors Maois occurs because mao inhibitor interaction with dextromethorphan; potentiation of anticholinergic and sympathomimetic effects. Clinically, this means hyperpyrexia, hypotension, and death reported with coadministration. mao inhibitors prolong/intensify anticholinergic effects and enhance pseudoephedrine effect. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.
What To Tell Your Doctor or Pharmacist
If you are taking Brompheniramine Maleate Pseudoephedrine Hydrochloride And De and your doctor is considering prescribing Monoamine Oxidase Inhibitors Maois (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider