Nitrous Oxide Interactions

Anesthetic that potentiates methotrexate effects on folate-dependent metabolic pathways, increasing risk of severe adverse reactions. Avoid use in methotrexate-treated patients.

Source: NLP:methotrexate

Nitrous oxide anesthesia potentiates methotrexate effects on folate-dependent metabolic pathways, increasing risk of severe adverse reactions. Avoid in patients receiving methotrexate.

Source: NLP:methotrexate sodium

Increased risk of methemoglobinemia when concurrently exposed to articaine.

Source: NLP:articaine hydrochloride and epinephrine

Increased risk of developing methemoglobinemia when concurrently exposed to this nitrous oxide.

Source: NLP:articaine hydrochloride, epinephrine bitartrate

Increased risk of methemoglobinemia when concurrently exposed to this nitrate/nitrite oxidizing agent with local anesthetics.

Source: NLP:benzocaine, butamben, and tetracaine hydrochloride

Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.

Source: NLP:bupivacaine hydrochloride

Increased risk of methemoglobinemia when used concurrently with lidocaine.

Source: NLP:lidocaine

Nitrite that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Source: NLP:lidocaine 5%

Nitrite drug that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.

Source: NLP:lidocaine and capsaicin

Nitrate/nitrite; increased risk of methemoglobinemia when concurrently exposed.

Source: NLP:lidocaine and prilocaine

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Source: NLP:lidocaine hydrochloride

Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.

Source: NLP:lidocaine hydrochloride and epinephrine bitartrate

Increased risk of methemoglobinemia when lidocaine is concurrently exposed to oxidizing agents.

Source: NLP:lidocaine and menthol

Increased risk of methemoglobinemia when local anesthetics are concurrently exposed to nitrous oxide.

Source: NLP:lidothol patch

Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites.

Source: NLP:marcaine, lidocaine, povidone iodine

Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.

Source: NLP:mepivacaine hydrochloride

CNS depressant that accentuates the sedative effect of midazolam, requiring dose adjustment.

Source: NLP:midazolam hydrochloride

Increased risk of methemoglobinemia when penicillin is concurrently administered with nitrous oxide.

Source: NLP:penicillin g benzathine and penicillin g procaine

Increased risk of methemoglobinemia when prilocaine is concurrently exposed to nitrous oxide.

Source: NLP:prilocaine hcl and epinephrine

Increased risk of methemoglobinemia when used concurrently with prilocaine.

Source: NLP:prilocaine hydrochloride

Increased risk of developing methemoglobinemia when concurrently exposed to nitrous oxide.

Source: NLP:ropivacaine hydrochloride

Increased risk of methemoglobinemia when concurrently exposed.

Source: NLP:bupivacaine hydrochloride, lidocaine hydrochloride, triamcinolone acetonide, povidine iodine

May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.

Source: NLP:bupivacaine

Concomitant use of N2O reduces the MAC of desflurane. Adjust dose accordingly.

Source: NLP:desflurane

Nitrous oxide indirectly decreases folate activity by inactivating vitamin B12 and downstream methylation pathways.

Source: NLP:folic acid

Nitrous oxide decreases the minimum alveolar concentration (MAC) of isoflurane. Dose adjustment required.

Source: NLP:isoflurane

Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites with bupivacaine.

Source: NLP:methylprednisolone acetate, bupivacaine hydrochloride, povidone-iodine

May increase anesthetic/sedative and cardiorespiratory effects; propofol dose may require adjustment during maintenance.

Source: NLP:propofol

Anesthetic requirement for sevoflurane is decreased when administered in combination with nitrous oxide; MAC equivalent dose requirement is reduced approximately 50% in adults.

Source: NLP:sevoflurane