Nitrous Oxide + Methotrexate Interaction
Contraindicatedinteraction on record
Description
Anesthetic that potentiates methotrexate effects on folate-dependent metabolic pathways, increasing risk of severe adverse reactions. Avoid use in methotrexate-treated patients.
Mechanism
Potentiates effect on folate-dependent metabolic pathways
Source: NLP:methotrexate