Nitrous Oxide + Methotrexate Sodium Interaction
Contraindicatedinteraction on record
Description
Nitrous oxide anesthesia potentiates methotrexate effects on folate-dependent metabolic pathways, increasing risk of severe adverse reactions. Avoid in patients receiving methotrexate.
Mechanism
Potentiates effect on folate-dependent metabolic pathways
Source: NLP:methotrexate sodium