45 interactions on record
NSAIDs should not be administered prior to or concomitantly with high-dose methotrexate. Concomitant administration has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and gastrointestinal toxicity.
Source: NLP:methotrexate
NSAIDs may result in deterioration of renal function and loss of antihypertensive effect with benazepril, especially in elderly or volume-depleted patients.
Source: NLP:amlodipine besylate and benazepril hydrochloride
Aspirin increases risk of peptic ulceration and bleeding with additive effects.
Source: NLP:butalbital, aspirin, and caffeine
Increases risk of gastrointestinal bleeding when coadministered with clopidogrel.
Source: NLP:clopidogrel bisulfate
Increased risk of renal impairment and acute renal failure, especially in elderly or volume-depleted patients. Reduced antihypertensive effects. Monitor renal function periodically.
Source: NLP:irbesartan
NSAIDs can reduce diuretic and antihypertensive effects, and may cause renal impairment including acute renal failure, especially in elderly or volume-depleted patients.
Source: NLP:irbesartan and hydrochlorothiazide
Concomitant administration may increase the risk of CNS stimulation and convulsive seizures.
Source: NLP:levofloxacin
Co-administration may result in deterioration of renal function, including possible acute renal failure, especially in elderly patients, those volume-depleted, or with compromised renal function. NSAIDs may also attenuate the antihypertensive effect.
Source: NLP:lisinopril and hydrochlorothiazide tablets
Risk of deterioration of renal function including possible acute renal failure, and reduced diuretic, natriuretic, and antihypertensive effects. Monitor renal function periodically.
Source: NLP:losartan potassium and hydrochlorothiazide
NSAIDs may result in deterioration of renal function, including acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. NSAIDs may also attenuate antihypertensive effect.
Source: NLP:moexipril hydrochloride
Concomitant use with NSAIDs may increase risk of CNS stimulation and convulsions.
Source: NLP:moxifloxacin hydrochloride
Concomitant NSAIDs with ofloxacin may increase risk of CNS stimulation and convulsive seizures.
Source: NLP:ofloxacin
NSAIDs may lead to increased risk of renal impairment and loss of antihypertensive effect. In elderly, volume-depleted, or renal-compromised patients, may result in deterioration of renal function including acute renal failure.
Source: NLP:olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide
NSAIDs may reduce diuretic, natriuretic, and antihypertensive effects; increased risk of renal toxicity and acute renal failure, particularly in elderly, volume-depleted, or renal-compromised patients.
Source: NLP:olmesartan medoxomil and hydrochlorothiazide
NSAIDs may produce potassium retention by reducing renal prostaglandin E synthesis and impairing the renin-angiotensin system. Monitor for hyperkalemia.
Source: NLP:potassium chloride
May produce potassium retention; closely monitor potassium levels during concomitant use.
Source: NLP:potassium citrate
May result in deterioration of renal function including possible acute renal failure in elderly, volume-depleted, or renal-compromised patients. May attenuate antihypertensive effect.
Source: NLP:telmisartan
NSAIDs may result in deterioration of renal function, including possible acute renal failure, and may attenuate the antihypertensive effect of ARBs. NSAIDs reduce diuretic, natriuretic, and antihypertensive effects.
Source: NLP:telmisartan and hydrochlorothiazide
NSAIDs may result in deterioration of renal function including possible acute renal failure, especially in elderly, volume-depleted, or renal-compromised patients. May attenuate antihypertensive effect.
Source: NLP:valsartan and hydrochlorothiazide
Blunting of the antihypertensive effect of acebutolol has been reported.
Source: NLP:acebutolol hydrochloride
NSAID use is associated with gastrointestinal irritation; caution should be used during concomitant use with alendronate sodium.
Source: NLP:alendronate sodium
Can reduce diuretic, natriuretic, and antihypertensive effects of amiloride HCl. Patient should be monitored to determine if desired diuretic effect is achieved.
Source: NLP:amiloride hydrochloride
NSAIAs may reduce diuretic, natriuretic, and antihypertensive effects. Patient should be observed closely to determine if desired diuretic effect is obtained.
Source: NLP:amiloride hydrochloride and hydrochlorothiazide
NSAIDs may lead to deterioration of renal function, acute renal failure, and loss of antihypertensive effect of olmesartan. Monitor renal function periodically.
Source: NLP:amlodipine and olmesartan medoxomil
Decline in GFR or tubular secretion may impair digoxin excretion. Individualize digoxin dosage and monitor.
Source: NLP:digoxin
May reduce antihypertensive effect and result in severe hyperkalemia in patients with impaired renal function; monitor blood pressure and serum potassium.
Source: NLP:eplerenone
NSAIDs may reduce the diuretic, natriuretic, and antihypertensive effects of ethacrynate sodium. Patient should be closely observed to ensure desired diuretic effect.
Source: NLP:ethacrynate sodium
NSAIAs may reduce the diuretic, natriuretic, and antihypertensive effects of ethacrynic acid; patient should be observed closely.
Source: NLP:ethacrynic acid
NSAIDs may reduce diuretic and antihypertensive effects of fosinopril sodium and hydrochlorothiazide; effects not fully studied.
Source: NLP:fosinopril sodium and hydrochlorothiazide
May potentiate hypoglycemic action of glyburide. Close observation for hypoglycemia recommended.
Source: NLP:glyburide
Highly protein-bound; may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Source: NLP:glimepiride
NSAIDs may potentiate hypoglycemic action of glipizide. Patient should be observed closely for hypoglycemia when initiated or withdrawn.
Source: NLP:glipizide
NSAIAs can reduce the diuretic, natriuretic, and antihypertensive effects of hydrochlorothiazide; close patient monitoring is recommended.
Source: NLP:hydrochlorothiazide
Caution should be exercised with concomitant use of NSAIDs and ibandronate as both are associated with gastrointestinal irritation.
Source: NLP:ibandronate sodium
May alter T4 and T3 serum transport.
Source: NLP:levothyroxine sodium
Concurrent use may increase risk of nephrotoxicity. Monitor patients for changes in renal function and mesalamine-related adverse reactions.
Source: NLP:mesalamine
Concomitant use may increase risks of CNS stimulation and convulsions.
Source: NLP:moxifloxacin
NSAIDs with moxifloxacin may increase risks of CNS stimulation and convulsions.
Source: NLP:moxifloxacin hydrochloride tablets, 400 mg
Chronic coadministration may increase the risk of bleeding.
Source: NLP:prasugrel
NSAIDs may reduce diuretic, natriuretic, and antihypertensive effects of spironolactone. Monitor closely for desired diuretic effect.
Source: NLP:spironolactone
Caution advised when administering NSAIDs with triamterene and hydrochlorothiazide due to risk of acute renal failure.
Source: NLP:triamterene and hydrochlorothiazide
Potentially nephrotoxic drugs; caution indicated when used with zoledronic acid due to increased risk of renal impairment.
Source: NLP:zoledronic acid
No dose adjustment needed when co-administered with montelukast sodium.
Source: NLP:montelukast
No dose adjustment needed when co-administered with montelukast sodium.
Source: NLP:montelukast sodium
No significant difference in upper gastrointestinal adverse experiences between placebo and risedronate-treated patients using NSAIDs.
Source: NLP:risedronate sodium