Nonsteroidal Anti Inflammatory Drugs (Nsaids) + Methotrexate Interaction
Contraindicatedinteraction on record
Description
NSAIDs should not be administered prior to or concomitantly with high-dose methotrexate. Concomitant administration has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and gastrointestinal toxicity.
Mechanism
Reduce tubular secretion of methotrexate
Source: NLP:methotrexate