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Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

NSAIDs reduce pain, fever, and inflammation by blocking COX enzymes. Common examples include ibuprofen, naproxen, and aspirin. They carry important interaction risks with blood thinners, ACE inhibitors, and other NSAIDs.

31 drugs in this class6 notable interactions shown

NSAIDs Drugs (31)

Acetaminophen And IbuprofenCombogesicAcetaminophen And Ibuprofen InjectionCombogesic IvAspirin And DipyridamoleAspirin And DipyridamoleAspirin And Extended - Release DipyridamoleAspirin And Extended - Release Dipyridamole Capsules, 25 Mg / 200 MgAsprin And Extended-Release DipyridamoleAsprin And Extended-Release DipyridamoleBupivacaine And MeloxicamZynrelefButalbital, Aspirin, And CaffeineButalbital, Aspirin, And CaffeineButalbital, Aspirin, Caffeine And Codeine PhosphateButalbital, Aspirin, Caffeine And Codeine PhosphateCelecoxibCelecoxibDiclofenacDiclofenac SodiumDiflunisalDiflunisalEtodolacEtodolacFlurbiprofenFlurbiprofenHydrocodone Bitartrate And IbuprofenHydrocodone Bitartrate And IbuprofenIbuprofenIbuIbuprofen And FamotidineIbuprofen And FamotidineIbuprofen OralIbuprofenIndomethacinIndomethacinKetoprofenKetoprofenMefenamic AcidMefenamic AcidMeloxicamMeloxicamMeloxicam, RizatriptanSymbravoNabumetoneNabumetoneNaproxenNaproxenNaproxen And Esomeprazole MagnesiumNaproxen And Esomeprazole MagnesiumNaproxen OralNaproxen Oral SuspensionNaproxen SodiumNaproxen SodiumOxaprozinOxaprozinOxycodone And AspirinOxycodone And AspirinPiroxicamPiroxicamSulindacSulindac

Notable NSAIDs Interactions

Acetaminophen And Ibuprofen + Acetylsalicylic Acid⚠️Major

Concomitant use of ibuprofen and aspirin increases risk of GI adverse reactions and bleeding; no greater therapeutic benefit than NSAID alone.

Acetaminophen And Ibuprofen + Warfarin⚠️Major

Ibuprofen and warfarin have synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Acetaminophen And Ibuprofen + Furosemide🟡Moderate

NSAIDs reduce natriuretic effect of loop diuretics like furosemide in some patients.

Acetaminophen And Ibuprofen Injection + Acetylsalicylic Acid⚠️Major

Concomitant use of NSAID and aspirin is associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Acetaminophen And Ibuprofen Injection + Warfarin⚠️Major

Ibuprofen and warfarin have synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Acetaminophen And Ibuprofen Injection + Furosemide🟡Moderate

NSAIDs reduced the natriuretic effect of loop diuretics. Monitor renal function and fluid status during concomitant use.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.