Meloxicam, Rizatriptan Interactions

Propranolol has been shown to increase the plasma AUC of rizatriptan. The concomitant use of SYMBRAVO with propranolol is contraindicated.

Source: FDA drug label - meloxicam, rizatriptan

Thus, concomitant usage of CYP2C9 inhibitors (e.g., amiodarone, fluconazole) may lead to abnormally high plasma levels of meloxicam due to reduced metabolic clearance [see Use in Specific Populations (8.8) , Clinical Pharmacology (12.3, 12.5)] .

Source: FDA drug label - meloxicam, rizatriptan

Diuretics: NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics. Diuretics Clinical Impact Clinical studies, as well as postmarketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. However, studies with furosemide agents and meloxicam have not demonstrated a reduction in natriuretic effect.

Source: FDA drug label - meloxicam, rizatriptan