Theophylline + Zileuton Interaction
Majorinteraction on record
Description
Zileuton significantly decreases theophylline clearance (~50%), doubling AUC and increasing Cmax by 73%. Theophylline-related adverse reactions occur more frequently. Reduce theophylline dose by approximately one-half and monitor plasma concentrations.
Mechanism
Decreased theophylline clearance and elimination
Source: NLP:zileuton