Zileuton + KetoconazoleUnknown
However, no formal drug-drug interaction studies between zileuton and CYP3A4 inhibitors, such as ketaconazole, have been conducted.
Source: FDA drug label - zileuton
Zileuton Interactions
Brand names: Zileuton
2 interactions on record
Zileuton + PropranololUnknown
(7.2) Zileuton increases propranolol levels and beta-blocker activity. 7.3 Propranolol Coadministration of zileuton immediate-release tablets and propranolol results in a significant increase in propranolol concentrations. Administration of a single 80 mg dose of propranolol in 16 healthy male subjects who received zileuton immediate-release tablets 600 mg every 6 hours for 5 days resulted in a 42% decrease in propranolol clearance.
Source: FDA drug label - zileuton