Nonsteroidal Anti Inflammatory Drugs Nsaids + Olmesartan Medoxomil Amlodipine Besylate Hydrochlorothiazide Interaction
Majorinteraction on record
Description
NSAIDs may lead to increased risk of renal impairment and loss of antihypertensive effect. In elderly, volume-depleted, or renal-compromised patients, may result in deterioration of renal function including acute renal failure.
Mechanism
NSAIDs inhibit prostaglandin synthesis, reducing renal perfusion and attenuating antihypertensive effects of angiotensin II receptor antagonists
Source: NLP:olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide