Midazolam In 08 Sodium Chloride + Morphine Interaction
Majorinteraction on record
Description
Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites. Sedative effect of midazolam is accentuated.
Mechanism
Benzodiazepines interact at GABA-A sites; opioids interact at mu receptors
Source: NLP:midazolam in 0.8% sodium chloride