Morphine Interactions

Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.

Source: NLP:alprazolam

Combined use of baclofen injection (intrathecal) and epidural morphine may result in hypotension and dyspnea.

Source: NLP:baclofen

Opioid agonist delays and reduces clopidogrel absorption, decreasing exposure to metabolites. Consider parenteral antiplatelet agent in acute coronary syndrome.

Source: NLP:clopidogrel

Opioid agonist that delays and reduces clopidogrel absorption, decreasing exposure to active metabolites. Consider parenteral antiplatelet agent in ACS patients.

Source: NLP:clopidogrel bisulfate

Coadministration may cause respiratory depression and sedation, sometimes resulting in death. Patients should be observed for CNS depression signs.

Source: NLP:gabapentin

Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respiratory depression and sedation.

Source: NLP:midazolam

Concomitant use increases risk of respiratory depression and sedation. Opioids interact at mu receptors while benzodiazepines act at GABA A sites, creating additive CNS depression.

Source: NLP:midazolam hydrochloride

May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood pressure and cardiac output.

Source: NLP:propofol

Opioid agonist delays and reduces absorption of ticagrelor and its active metabolite through slowed gastric emptying.

Source: NLP:ticagrelor

Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for common renal tubular transport systems.

Source: NLP:metformin hcl

CHCs have been shown to decrease plasma concentrations of morphine.

Source: NLP:norelgestromin and ethinyl estradiol

Oral contraceptives may induce conjugation of morphine, increasing its clearance.

Source: NLP:norethindrone acetate and ethinyl estradiol and ferrous fumarate

Oral contraceptives may induce conjugation of morphine, increasing its clearance and decreasing plasma concentrations.

Source: NLP:norethindrone acetate and ethinyl estradiol

Opioid agonists delay and reduce absorption of prasugrel's active metabolite, presumably due to slowed gastric emptying.

Source: NLP:prasugrel

May increase serum concentration of trospium and/or morphine due to competition for renal tubular secretion. Careful patient monitoring is recommended.

Source: NLP:trospium chloride

Alvimopan does not significantly alter the pharmacokinetics of intravenous morphine or its metabolite morphine-6-glucuronide. No dosage adjustment necessary.

Source: NLP:alvimopan