Levothyroxine Sodium + Phenobarbital Interaction
Majorinteraction on record
Description
Increases L-thyroxine metabolism by inducing UGT, leading to lower T4 serum levels and increased levothyroxine requirements. Changes in thyroid status may occur if added or withdrawn.
Mechanism
Stimulates hepatic microsomal drug-metabolizing enzyme activity; induces UGT
Source: NLP:levothyroxine sodium