Phenobarbital Interactions

Brand names: Phenobarbital

2 interactions on record

Phenobarbital + DoxycyclineUnknown

Doxycycline Phenobarbital has been shown to shorten the half-life of doxycycline for as long as 2 weeks after barbiturate therapy is discontinued. If phenobarbital and doxycycline are administered concurrently, the clinical response to doxycycline should be monitored closely.

Source: FDA drug label - phenobarbital

Phenobarbital + ProgesteroneUnknown

Estradiol, Estrone Progesterone, and Other Steroidal Hormones Pretreatment with or concurrent administration of phenobarbital may decrease the effect of estradiol by increasing its metabolism.

Source: FDA drug label - phenobarbital