Itraconazole + Phenobarbital Interaction
Majorinteraction on record
Description
Potent CYP3A4 enzyme inducer that may decrease itraconazole bioavailability and efficacy. Avoid use 2 weeks before and during itraconazole treatment.
Mechanism
CYP3A4 enzyme induction decreases itraconazole bioavailability
Source: NLP:itraconazole