Dicumarol + Phenobarbital Sodium Interaction
Majorinteraction on record
Description
Phenobarbital lowers plasma levels of dicumarol and decreases anticoagulant activity. Barbiturates induce hepatic microsomal enzymes resulting in increased metabolism and decreased anticoagulant response.
Mechanism
Induction of hepatic microsomal enzymes
Source: NLP:phenobarbital sodium