SGLT2 Inhibitors

SGLT2 inhibitors lower blood sugar in type 2 diabetes by causing the kidneys to excrete glucose. They interact with diuretics, insulin, and drugs that affect kidney function.

10 drugs in this class6 notable interactions shown

SGLT2 Inhibitors Drugs (10)

BexagliflozinBrenzavvy DapagliflozinDapagliflozin Dapagliflozin And Metformin HydrochlorideDapagliflozin And Metformin Hydrochloride Dapagliflozin And SaxagliptinDapagliflozin And Saxagliptin EmpagliflozinJardiance Empagliflozin And LinagliptinGlyxambi Empagliflozin And Metformin HydrochlorideSynjardy Empagliflozin, Linagliptin, Metformin HydrochlorideTrijardy Xr Empagliflozin, Metformin HydrochlorideSynjardy Xr SotagliflozinInpefa

Notable SGLT2 Inhibitors Interactions

Bexagliflozin + Insulin Human⚠️Major

Concomitant use increases risk of hypoglycemia. A lower dose of insulin may be required when used in combination with bexagliflozin.

Bexagliflozin + Lithium🟡Moderate

Bexagliflozin may decrease serum lithium concentrations. Monitor serum lithium concentration more frequently upon initiation and discontinuation.

Bexagliflozin + Ugt Enzyme Inducers🟡Moderate

UGT enzyme inducers may significantly reduce bexagliflozin exposure and lead to decreased efficacy. Consider adding another antihyperglycemic agent for additional glycemic control.

Dapagliflozin + Insulin Human⚠️Major

Risk of hypoglycemia may be increased when dapagliflozin is used concomitantly with insulin. Concomitant use may require lower doses of insulin to reduce hypoglycemia risk.

Dapagliflozin + Sulfonylurea⚠️Major

Risk of hypoglycemia may be increased when dapagliflozin is used concomitantly with sulfonylurea insulin secretagogues. Concomitant use may require lower doses to reduce hypoglycemia risk.

Dapagliflozin + Lithium🟡Moderate

Concomitant use of dapagliflozin with lithium may decrease serum lithium concentrations. Monitor serum lithium concentration more frequently during dapagliflozin initiation and dosage changes.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.