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Retinoids

Retinoids are vitamin A derivatives used for acne, psoriasis, and certain cancers. They interact with vitamin A supplements, tetracyclines, and methotrexate — with some combinations causing serious toxicity.

13 drugs in this class6 notable interactions shown

Retinoids Drugs (13)

AcitretinAcitretinAdapaleneAdapaleneAdapalene And Benzoyl PeroxideAdapalene And Benzoyl PeroxideAdapalene And Benzoyl Peroxide Gel, 0.1%/2.5%Adapalene And Benzoyl Peroxide Gel, 0.1%/2.5%BexaroteneBexaroteneClindamycin Phosphate And TretinoinClindamycin Phosphate 1.2% And Tretinoin 0.025%Clindamycin Phosphate And Tretinoin Gel 1.2%/0.025%Clindamycin Phosphate And Tretinoin Gel 1.2%/0.025%Clindamycin Phosphate/Benzoyl Peroxide/AdapaleneCabtreoIsotretinoinIsotretinoinPalovaroteneSohonosTazaroteneTazaroteneTretinoinTretinoinTrifaroteneAklief

Notable Retinoids Interactions

Acitretin + Alcohol⛔Contraindicated

Concurrent ingestion of acitretin and ethanol can result in formation of etretinate.

Acitretin + Doxycycline⛔Contraindicated

Both acitretin and tetracyclines can cause increased intracranial pressure; concurrent use should be avoided.

Acitretin + Iron-Containing Preparations⛔Contraindicated

Acitretin interferes with the contraceptive effect of microdosed progestin-only preparations (minipills). These are not recommended for use with acitretin.

Adapalene + Resorcinol🟡Moderate

Particular caution advised when using resorcinol preparations with adapalene cream due to potential for increased local irritation.

Adapalene + Salicylic Acid🟡Moderate

Particular caution advised when using salicylic acid preparations with adapalene cream due to potential for increased local irritation.

Adapalene + Sulfur🟡Moderate

Particular caution advised when using sulfur preparations with adapalene cream due to potential for increased local irritation.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.