Home›Drug Classes›P-gp Inhibitors

P-Glycoprotein Inhibitors

P-glycoprotein is a drug efflux transporter that limits the absorption and distribution of many medications. P-gp inhibitors increase exposure to drugs like digoxin, anticoagulants, and certain cancer therapies.

61 drugs in this class6 notable interactions shown

P-gp Inhibitors Drugs (61)

AbrocitinibAtazanavir And CobicistatEvotazAvapritinibAyvakitClarithromycinCobicistatTybostCrizotinibCyclosporineNeoralDanicopanVoydeyaDarunavir Ethanolate And CobicistatPrezcobixDarunavir, Cobicistat, Emtricitabine, And Tenofovir AlafenamideSymtuzaElacestrantOrserduEliglustatCerdelgaElvitegravir, Cobicistat, Emtricitabine, And Tenofovir AlafenamideGenvoyaElvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil FumarateStribildErdafitinibBalversaEtravirineEtravirineFlibanserinAddyiGlecaprevir And PibrentasvirMavyretImlunestrantInluriyoItraconazoleIvacaftorKalydecoKetoconazoleLedipasvir And SofosbuvirLedipasvir And SofosbuvirLevacetylleucineAqneursaLevoketoconazoleRecorlevLonafarnibZokinvyLopinavir And RitonavirLopinavir And RitonavirLumacaftor And IvacaftorOrkambiMaribavirLivtencityMavorixaforXolremdiMirabegronMirabegronMitapivatAqvesmeNetupitant And PalonosetronAkynzeoNilotinibPacritinibVonjoPemigatinibPemazyrePirtobrutinibJaypircaRanolazineRanolazineRelugolixOrgovyxRelugolix, Estradiol Hemihydrate, And Norethindrone AcetateMyfembreeRemibrutinibRhapsidoRilzabrutinibWayrilzRipretinibQinlockRitonavirRitonavir 100 MgRitonavir Film CoatedSelpercatinibRetevmoSofosbuvir, Velpatasvir, And VoxilaprevirVoseviSotagliflozinInpefaSparsentanFilspariSuvorexantBelsomraTicagrelorTicagrelorTucatinibTukysaVandetanibVanzacaftor, Tezacaftor, And DeutivacaftorAlyftrekVelpatasvir And SofosbuvirSofosbuvir And VelpatasvirVemurafenibVenetoclaxVenclextaVimseltinibRomvimzaVoclosporinLupkynisXanomeline And Trospium ChlorideCobenfyZonisamide

Notable P-gp Inhibitors Interactions

Abrocitinib + Fluconazole⛔Contraindicated

Concomitant use increases systemic exposure of abrocitinib and active metabolites due to fluconazole's inhibition of CYP2C19, CYP2C9, and CYP3A4. Avoid concomitant use.

Abrocitinib + Digoxin⚠️Major

Coadministration increases plasma concentrations of digoxin, a P-gp substrate where small concentration changes may lead to serious or life-threatening toxicities.

Abrocitinib + Steroid Therapy⚠️Major

Coadministration may increase the risk of bleeding with thrombocytopenia.

Atazanavir And Cobicistat + Alfuzosin⛔Contraindicated

Other Agents Alpha 1-adrenoreceptor antagonist: alfuzosin ↑ alfuzosin Coadministration of EVOTAZ with alfuzosin is contraindicated due to the potential for increased alfuzosin concentrations, which can result in hypotension [see Contraindications (4) ] .

Atazanavir And Cobicistat + Apalutamide⛔Contraindicated

Antineoplastics: apalutamide ↓ atazanavir ↓cobicistat Coadministration with apalutamide is contraindicated due to the potential for substantial decrease in plasma concentrations of atazanavir and cobicistat, which may result in loss of virologic response of EVOTAZ and possible resistance to atazanavir or to other protease inhibitors. Mechanism: The mechanism of interaction is CYP3A4 induction by apalutamide.

Atazanavir And Cobicistat + Efavirenz, Emtricitabine And Tenofovir Disoproxil Fumarate⛔Contraindicated

Coadministration is not recommended. Combined effect on atazanavir plasma concentrations uncertain.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.