CYP3A4 Inducers

CYP3A4 inducers speed up the metabolism of drugs processed by this enzyme, reducing their effectiveness. Common examples include rifampin, carbamazepine, and St. John's Wort.

37 drugs in this class6 notable interactions shown

CYP3A4 Inducers Drugs (37)

AprepitantAponvie BelzutifanWelireg BrigatinibAlunbrig CarbamazepineCarbamazepine CenobamateXcopri ClobazamClobazam DeferasiroxDeferasirox EfavirenzEfavirenz Efavirenz, Emtricitabine And Tenofovir Disoproxil FumarateEfavirenz, Emtricitabine And Tenofovir Disoproxil Fumarate Efavirenz, Lamivudine And Tenofovir Disoproxil FumarateSymfi ElafibranorIqirvo Enzalutamide ErdafitinibBalversa EtravirineEtravirine Ivosidenib Lopinavir And RitonavirLopinavir And Ritonavir LorlatinibLorbrena Lumacaftor And IvacaftorOrkambi MitapivatAqvesme MitotaneLysodren NevirapineNevirapine OmaveloxoloneSkyclarys OritavancinOrbactiv OsimertinibTagrisso Phentermine And TopiramateQsymia Phentermine And Topiramate Extended-ReleasePhentermine And Topiramate Extended-Release PhenytoinPhenytoin Infatabs RelugolixOrgovyx Relugolix, Estradiol Hemihydrate, And Norethindrone AcetateMyfembree RepotrectinibAugtyro Ritonavir Ritonavir 100 MgRitonavir Film Coated SuzetrigineJournavx Tecovirimat MonohydrateTpoxx TopiramateTopiramate TovorafenibOjemda VorasidenibVoranigo

Notable CYP3A4 Inducers Interactions

Aprepitant + Pimozide⛔Contraindicated

Increased pimozide exposure. CINVANTI is contraindicated.

Aprepitant + Alprazolam⚠️Major

Increased alprazolam exposure may increase risk of adverse reactions with 3-day aprepitant regimen; monitor for benzodiazepine-related adverse reactions.

Aprepitant + Carbamazepine⚠️Major

Strong CYP3A4 inducer substantially decreases aprepitant exposure, which may decrease efficacy. Avoid concomitant use.

Belzutifan + Oral Contraceptives⚠️Major

Coadministration may lead to contraceptive failure or increase in breakthrough bleeding.

Belzutifan + Mao Inhibitors🟡Moderate

Coadministration increases belzutifan exposure. Monitor for anemia and hypoxia; reduce belzutifan dosage as recommended.

Brigatinib + Cyp3a Inducers🟡Moderate

Coadministration decreases brigatinib plasma concentrations, which may decrease the efficacy of ALUNBRIG. Coadministration should be avoided.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.