Antiarrhythmic Drugs

Antiarrhythmics control abnormal heart rhythms. Many are potent CYP450 inhibitors and prolong the QT interval, creating serious interaction risks with other cardiac drugs, antibiotics, and antifungals.

13 drugs in this class6 notable interactions shown

Antiarrhythmics Drugs (13)

DofetilideDofetilide DronedaroneMultaq LidexaLidexa LidocaineLidocaine Lidocaine 5%Lidocaine 5%Lidocaine And CapsaicinTrubrexa Lidocaine And PrilocaineLidocaine And Prilocaine Lidocaine And TetracainePliaglis Lidocaine Patch 5%Lidoderm Lidocaine, MentholGen7t Plus Lidothol Es PatchLidothol Es Patch Lidothol PatchLidothol Patch Trubrexa Patch ErTrubrexa Patch Er

Notable Antiarrhythmics Interactions

Dofetilide + Abacavir Sulfate, Dolutegravir Sodium, Lamivudine⛔Contraindicated

Dolutegravir inhibits OCT2, may increase plasma concentrations of dofetilide, a drug eliminated via OCT2.

Dofetilide + Cimetidine⛔Contraindicated

Cimetidine 400 mg BID increases dofetilide plasma levels by 58%. Concomitant use is contraindicated.

Dofetilide + Dolutegravir Sodium And Rilpivirine Hydrochloride⛔Contraindicated

Dolutegravir inhibits OCT2 and MATE1, increasing dofetilide plasma concentrations. Consider alternatives due to risk of Torsade de Pointes.

Dronedarone + Clarithromycin⛔Contraindicated

7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole as well as other potent CYP3A inhibitors such as itraconazole, voriconazole, ritonavir, clarithromycin, and nefazodone is contraindicated because exposure to dronedarone is significantly increased [see Contraindications (4) , Clinical Pharmacology (12.3) ] .

Dronedarone + Class Iii Antiarrhythmics⛔Contraindicated

Contraindicated due to potential risk of torsade de pointes-type ventricular tachycardia.

Dronedarone + Iobenguane I-123⛔Contraindicated

Contraindicated due to potential risk of torsade de pointes-type ventricular tachycardia.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.