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Anti-Epileptic Drugs (AEDs)

Anti-epileptic drugs prevent seizures and are also used for neuropathic pain and bipolar disorder. Many are CYP450 inducers or inhibitors, creating extensive interaction networks with other medications.

11 drugs in this class6 notable interactions shown

Anti-Epileptics Drugs (11)

EthosuximideFelbamateFelbamateLamotrigineLamotrigineLamotrigine Chewable DispersibleLamotrigineLamotrigine Extended-ReleaseLamotrigineMethsuximideOxcarbazepineOxcarbazepinePhenytoinPhenytoin InfatabsValproic AcidValproic AcidVigabatrinVigabatrinZonisamide

Notable Anti-Epileptics Interactions

Ethosuximide + Dextroamphetamine Saccharate And Amphetamine Aspartate And Dextroamphetamine Sulfate And Amphetamine Sulfate🟡Moderate

Amphetamines may delay intestinal absorption of ethosuximide.

Ethosuximide + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate🟡Moderate

Amphetamines may reduce the effects of this drug. Monitor for reduced efficacy.

Ethosuximide + Divalproex Sodium🟡Moderate

Valproate can affect the pharmacokinetics of ethosuximide by inhibiting its metabolism or protein binding displacement.

Felbamate + Carbamazepine⚠️Major

Felbamate decreases steady-state carbamazepine plasma concentrations by 31% while increasing carbamazepine epoxide concentrations by 57%, potentially reducing carbamazepine efficacy.

Felbamate + Divalproex Sodium⚠️Major

Enzyme inhibitor that decreases valproate clearance. Increased monitoring of valproate concentrations and dosage adjustment indicated.

Felbamate + Levonorgestrel/Ethinyl Estradiol And Ethinyl Estradiol⚠️Major

Increases metabolism of contraceptive steroids, reducing contraceptive effectiveness and potentially resulting in unintended pregnancy or unscheduled bleeding.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.