Zidovudine + Clarithromycin Interaction

Moderateinteraction on record

Description

Simultaneous oral administration may decrease steady-state zidovudine concentrations by 12% on average. When clarithromycin is given 2-4 hours prior to zidovudine, zidovudine Cmax increases 100%.

Mechanism

Clarithromycin affects zidovudine absorption and metabolism

Source: NLP:clarithromycin