Warfarin + Naproxen And Esomeprazole Magnesium Interaction
Majorinteraction on record
Description
Naproxen and warfarin have synergistic effect on bleeding with increased risk of serious bleeding. Esomeprazole increases INR and prothrombin time with warfarin, potentially leading to abnormal bleeding and death.
Mechanism
Synergistic effect on bleeding; PPI increases INR and prothrombin time
Source: NLP:naproxen and esomeprazole magnesium