Warfarin + Duloxetine Interaction
Moderateinteraction on record
Description
Monitor carefully when initiating or discontinuing duloxetine. Altered anticoagulant effects and increased bleeding reported with SNRIs; however, duloxetine did not significantly affect INR or warfarin pharmacokinetics in clinical study.
Mechanism
Platelet dysfunction and potential serotonergic effects on hemostasis
Source: NLP:duloxetine