Venlafaxine Hydrochloride + Cimetidine Interaction
Moderateinteraction on record
Description
Cimetidine reduces venlafaxine oral clearance by 43% and increases AUC and Cmax by 60%. Caution advised in patients with hypertension, elderly patients, or those with hepatic dysfunction.
Mechanism
Inhibition of first-pass metabolism of venlafaxine
Source: NLP:venlafaxine hydrochloride